![]() ![]() There were similar reductions in mean arterial pressure following treatment with atenolol and metoprolol succinate. ![]() Measures of vascular function included peripheral augmentation index (AIx) and pulse wave amplitude reactive hyperemia index from peripheral arterial tonometry, and brachial artery flow-mediated dilation from ultrasound. Each β-blocker (atenolol or metoprolol succinate) was taken by patients once daily for a 4-week period. This study included 24 patients with hypertension (age 56 ± 2 years, 8 female, body mass index 28 ± 1) and featured a randomized, double-blind, crossover design. Given intrinsic differences between these agents, we hypothesized that atenolol and metoprolol succinate would have disparate effects on vascular function. ![]() We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension.
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