There were similar reductions in mean arterial pressure following treatment with atenolol and metoprolol succinate. Measures of vascular function included peripheral augmentation index (AIx) and pulse wave amplitude reactive hyperemia index from peripheral arterial tonometry, and brachial artery flow-mediated dilation from ultrasound. Each β-blocker (atenolol or metoprolol succinate) was taken by patients once daily for a 4-week period. This study included 24 patients with hypertension (age 56 ± 2 years, 8 female, body mass index 28 ± 1) and featured a randomized, double-blind, crossover design. Given intrinsic differences between these agents, we hypothesized that atenolol and metoprolol succinate would have disparate effects on vascular function. We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension.
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